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p re ss syn1 cre mice  (Jackson Laboratory)

 
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    Jackson Laboratory p re ss syn1 cre mice
    P Re Ss Syn1 Cre Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Average 86 stars, based on 1 article reviews
    p re ss syn1 cre mice - by Bioz Stars, 2026-05
    86/100 stars

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    p re ss syn1 cre mice  (Jackson Laboratory)
    86
    Jackson Laboratory p re ss syn1 cre mice
    P Re Ss Syn1 Cre Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p re ss syn1 cre mice/product/Jackson Laboratory
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    syn1 cre mice  (Jackson Laboratory)
    86
    Jackson Laboratory syn1 cre mice
    A Schematic diagram of generation of neuron-specific Slc7a5 knockout mice. B Kaplan–Meier survival analysis of Slc7a5 fl/fl ( n = 8) and <t>Syn1-Cre;Slc7a5</t> fl/fl mice ( n = 12). C Schematic diagram of behavioral analyses in Slc7a5 fl/fl and Syn1-Cre;Slc7a5 fl/fl mice. D Body weight of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 22) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 10). E – G Quantitative data of hindlimb suspension test; ( E ) latency to fall (seconds), ( F ) number of pulls, and ( G ) hindlimb score of Slc7a5 fl/fl (1 week and 2 week: n = 20) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 7). Solid bars represent the results of the first trial, while dashed bars represent the results of the second trial. H Quantitative data of negative geotaxis test; latency to upward (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). I – K Representative pictures and quantitative data of tail suspension test (self-clasping test); ( J ) clasping time (seconds), and ( K ) clasping score of Slc7a5 fl/fl (1 week: n = 11; 2 week: n = 21) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 8). L Quantitative data of righting reflex test; latency to right (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). NS not significant. * P < 0.05, ** P < 0.01, and *** P < 0.001.
    Syn1 Cre Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    syn1 cre mice  (Cyagen Biosciences)
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    Cyagen Biosciences syn1 cre mice
    A Schematic diagram of generation of neuron-specific Slc7a5 knockout mice. B Kaplan–Meier survival analysis of Slc7a5 fl/fl ( n = 8) and <t>Syn1-Cre;Slc7a5</t> fl/fl mice ( n = 12). C Schematic diagram of behavioral analyses in Slc7a5 fl/fl and Syn1-Cre;Slc7a5 fl/fl mice. D Body weight of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 22) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 10). E – G Quantitative data of hindlimb suspension test; ( E ) latency to fall (seconds), ( F ) number of pulls, and ( G ) hindlimb score of Slc7a5 fl/fl (1 week and 2 week: n = 20) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 7). Solid bars represent the results of the first trial, while dashed bars represent the results of the second trial. H Quantitative data of negative geotaxis test; latency to upward (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). I – K Representative pictures and quantitative data of tail suspension test (self-clasping test); ( J ) clasping time (seconds), and ( K ) clasping score of Slc7a5 fl/fl (1 week: n = 11; 2 week: n = 21) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 8). L Quantitative data of righting reflex test; latency to right (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). NS not significant. * P < 0.05, ** P < 0.01, and *** P < 0.001.
    Syn1 Cre Mice, supplied by Cyagen Biosciences, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    fto syn1 cre mice  (Jackson Laboratory)
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    Jackson Laboratory fto syn1 cre mice
    A Schematic diagram of generation of neuron-specific Slc7a5 knockout mice. B Kaplan–Meier survival analysis of Slc7a5 fl/fl ( n = 8) and <t>Syn1-Cre;Slc7a5</t> fl/fl mice ( n = 12). C Schematic diagram of behavioral analyses in Slc7a5 fl/fl and Syn1-Cre;Slc7a5 fl/fl mice. D Body weight of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 22) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 10). E – G Quantitative data of hindlimb suspension test; ( E ) latency to fall (seconds), ( F ) number of pulls, and ( G ) hindlimb score of Slc7a5 fl/fl (1 week and 2 week: n = 20) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 7). Solid bars represent the results of the first trial, while dashed bars represent the results of the second trial. H Quantitative data of negative geotaxis test; latency to upward (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). I – K Representative pictures and quantitative data of tail suspension test (self-clasping test); ( J ) clasping time (seconds), and ( K ) clasping score of Slc7a5 fl/fl (1 week: n = 11; 2 week: n = 21) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 8). L Quantitative data of righting reflex test; latency to right (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). NS not significant. * P < 0.05, ** P < 0.01, and *** P < 0.001.
    Fto Syn1 Cre Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    syn1-cre male mice  (Jackson Laboratory)
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    Jackson Laboratory syn1-cre male mice
    A Schematic diagram of generation of neuron-specific Slc7a5 knockout mice. B Kaplan–Meier survival analysis of Slc7a5 fl/fl ( n = 8) and <t>Syn1-Cre;Slc7a5</t> fl/fl mice ( n = 12). C Schematic diagram of behavioral analyses in Slc7a5 fl/fl and Syn1-Cre;Slc7a5 fl/fl mice. D Body weight of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 22) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 10). E – G Quantitative data of hindlimb suspension test; ( E ) latency to fall (seconds), ( F ) number of pulls, and ( G ) hindlimb score of Slc7a5 fl/fl (1 week and 2 week: n = 20) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 7). Solid bars represent the results of the first trial, while dashed bars represent the results of the second trial. H Quantitative data of negative geotaxis test; latency to upward (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). I – K Representative pictures and quantitative data of tail suspension test (self-clasping test); ( J ) clasping time (seconds), and ( K ) clasping score of Slc7a5 fl/fl (1 week: n = 11; 2 week: n = 21) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 8). L Quantitative data of righting reflex test; latency to right (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). NS not significant. * P < 0.05, ** P < 0.01, and *** P < 0.001.
    Syn1 Cre Male Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    hemizygous syn1 cre female mice  (Jackson Laboratory)
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    Jackson Laboratory hemizygous syn1 cre female mice
    A Schematic diagram of generation of neuron-specific Slc7a5 knockout mice. B Kaplan–Meier survival analysis of Slc7a5 fl/fl ( n = 8) and <t>Syn1-Cre;Slc7a5</t> fl/fl mice ( n = 12). C Schematic diagram of behavioral analyses in Slc7a5 fl/fl and Syn1-Cre;Slc7a5 fl/fl mice. D Body weight of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 22) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 10). E – G Quantitative data of hindlimb suspension test; ( E ) latency to fall (seconds), ( F ) number of pulls, and ( G ) hindlimb score of Slc7a5 fl/fl (1 week and 2 week: n = 20) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 7). Solid bars represent the results of the first trial, while dashed bars represent the results of the second trial. H Quantitative data of negative geotaxis test; latency to upward (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). I – K Representative pictures and quantitative data of tail suspension test (self-clasping test); ( J ) clasping time (seconds), and ( K ) clasping score of Slc7a5 fl/fl (1 week: n = 11; 2 week: n = 21) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 8). L Quantitative data of righting reflex test; latency to right (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). NS not significant. * P < 0.05, ** P < 0.01, and *** P < 0.001.
    Hemizygous Syn1 Cre Female Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    A Schematic diagram of generation of neuron-specific Slc7a5 knockout mice. B Kaplan–Meier survival analysis of Slc7a5 fl/fl ( n = 8) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 12). C Schematic diagram of behavioral analyses in Slc7a5 fl/fl and Syn1-Cre;Slc7a5 fl/fl mice. D Body weight of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 22) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 10). E – G Quantitative data of hindlimb suspension test; ( E ) latency to fall (seconds), ( F ) number of pulls, and ( G ) hindlimb score of Slc7a5 fl/fl (1 week and 2 week: n = 20) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 7). Solid bars represent the results of the first trial, while dashed bars represent the results of the second trial. H Quantitative data of negative geotaxis test; latency to upward (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). I – K Representative pictures and quantitative data of tail suspension test (self-clasping test); ( J ) clasping time (seconds), and ( K ) clasping score of Slc7a5 fl/fl (1 week: n = 11; 2 week: n = 21) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 8). L Quantitative data of righting reflex test; latency to right (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). NS not significant. * P < 0.05, ** P < 0.01, and *** P < 0.001.

    Journal: Cell Death & Disease

    Article Title: The amino acid transporter LAT1 coordinates proper motor function at the perinatal stage

    doi: 10.1038/s41419-026-08663-8

    Figure Lengend Snippet: A Schematic diagram of generation of neuron-specific Slc7a5 knockout mice. B Kaplan–Meier survival analysis of Slc7a5 fl/fl ( n = 8) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 12). C Schematic diagram of behavioral analyses in Slc7a5 fl/fl and Syn1-Cre;Slc7a5 fl/fl mice. D Body weight of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 22) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 10). E – G Quantitative data of hindlimb suspension test; ( E ) latency to fall (seconds), ( F ) number of pulls, and ( G ) hindlimb score of Slc7a5 fl/fl (1 week and 2 week: n = 20) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 7). Solid bars represent the results of the first trial, while dashed bars represent the results of the second trial. H Quantitative data of negative geotaxis test; latency to upward (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). I – K Representative pictures and quantitative data of tail suspension test (self-clasping test); ( J ) clasping time (seconds), and ( K ) clasping score of Slc7a5 fl/fl (1 week: n = 11; 2 week: n = 21) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 8). L Quantitative data of righting reflex test; latency to right (seconds) of Slc7a5 fl/fl (1 week: n = 20; 2 week: n = 25) and Syn1-Cre;Slc7a5 fl/fl mice (1 week: n = 7; 2 week: n = 9). NS not significant. * P < 0.05, ** P < 0.01, and *** P < 0.001.

    Article Snippet: Syn1-Cre mice (#003966) were obtained from Jackson Laboratory.

    Techniques: Knock-Out, Suspension

    A Schematic diagram of histological analyses in Slc7a5 fl/fl and Syn1-Cre;Slc7a5 fl/fl mice. B – E Immunofluorescent images and quantitative data of ChAT/DAPI staining in lumbar spinal cord; ( C ) the number of ChAT positive cell, and ( D , E ) the distribution of cell body area (μm 2 ) of Slc7a5 fl/fl (1 week and 2 week: n = 6) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 6). Arrowheads indicate representative ChAT positive cells. F – H Immunofluorescent images and quantitative data of NeuN staining in lumbar spinal cord; ( G ) the number of NeuN positive cell (/mm 2 ), and ( H ) NeuN immunointensity of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. Arrowheads indicate representative NeuN-positive cells. I , J Immunofluorescent images and quantitative data of cleaved caspase 3/ChAT/DAPI staining in lumbar spinal cord; ( J ) the number of cleaved caspase 3 and ChAT double positive cells of Slc7a5 fl/fl ( n = 6) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 6) at 1 week of age. Arrowheads indicate representative cleaved caspase 3, ChAT, and double-positive cells. K , L Immunofluorescent images and quantitative data of LC3B/ChAT/DAPI staining in lumbar spinal cord; ( L ) the number of LC3B and ChAT double positive cells of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 1 week of age. Arrowheads indicate representative LC3B, ChAT, and double positive cells. NS not significant, VH ventral horn, DH dorsal horn. * P < 0.05, ** P < 0.01, and *** P < 0.001.

    Journal: Cell Death & Disease

    Article Title: The amino acid transporter LAT1 coordinates proper motor function at the perinatal stage

    doi: 10.1038/s41419-026-08663-8

    Figure Lengend Snippet: A Schematic diagram of histological analyses in Slc7a5 fl/fl and Syn1-Cre;Slc7a5 fl/fl mice. B – E Immunofluorescent images and quantitative data of ChAT/DAPI staining in lumbar spinal cord; ( C ) the number of ChAT positive cell, and ( D , E ) the distribution of cell body area (μm 2 ) of Slc7a5 fl/fl (1 week and 2 week: n = 6) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 6). Arrowheads indicate representative ChAT positive cells. F – H Immunofluorescent images and quantitative data of NeuN staining in lumbar spinal cord; ( G ) the number of NeuN positive cell (/mm 2 ), and ( H ) NeuN immunointensity of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. Arrowheads indicate representative NeuN-positive cells. I , J Immunofluorescent images and quantitative data of cleaved caspase 3/ChAT/DAPI staining in lumbar spinal cord; ( J ) the number of cleaved caspase 3 and ChAT double positive cells of Slc7a5 fl/fl ( n = 6) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 6) at 1 week of age. Arrowheads indicate representative cleaved caspase 3, ChAT, and double-positive cells. K , L Immunofluorescent images and quantitative data of LC3B/ChAT/DAPI staining in lumbar spinal cord; ( L ) the number of LC3B and ChAT double positive cells of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 1 week of age. Arrowheads indicate representative LC3B, ChAT, and double positive cells. NS not significant, VH ventral horn, DH dorsal horn. * P < 0.05, ** P < 0.01, and *** P < 0.001.

    Article Snippet: Syn1-Cre mice (#003966) were obtained from Jackson Laboratory.

    Techniques: Staining

    A – C Immunofluorescent images and quantitative data of GFAP staining in lumbar spinal cord; ( B ) the number of GFAP positive cell (/mm 2 ), and ( C ) GFAP immunointensity of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. Arrowheads indicate representative GFAP-positive cells. D – F Immunofluorescent images and quantitative data of MAG staining in lumbar spinal cord; ( E ) the number of MAG positive cell (/mm 2 ), and ( F ) MAG immunointensity of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. G – I Immunofluorescent images and quantitative data of Iba1 staining in lumbar spinal cord; ( H ) the number of Iba1 positive cell (/mm 2 ), and (I) Iba1 immunointensity of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. Arrowheads indicate representative Iba1 positive cells. NS not significant, GM gray matter, WH white matter. * P < 0.05 and ** P < 0.01.

    Journal: Cell Death & Disease

    Article Title: The amino acid transporter LAT1 coordinates proper motor function at the perinatal stage

    doi: 10.1038/s41419-026-08663-8

    Figure Lengend Snippet: A – C Immunofluorescent images and quantitative data of GFAP staining in lumbar spinal cord; ( B ) the number of GFAP positive cell (/mm 2 ), and ( C ) GFAP immunointensity of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. Arrowheads indicate representative GFAP-positive cells. D – F Immunofluorescent images and quantitative data of MAG staining in lumbar spinal cord; ( E ) the number of MAG positive cell (/mm 2 ), and ( F ) MAG immunointensity of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. G – I Immunofluorescent images and quantitative data of Iba1 staining in lumbar spinal cord; ( H ) the number of Iba1 positive cell (/mm 2 ), and (I) Iba1 immunointensity of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. Arrowheads indicate representative Iba1 positive cells. NS not significant, GM gray matter, WH white matter. * P < 0.05 and ** P < 0.01.

    Article Snippet: Syn1-Cre mice (#003966) were obtained from Jackson Laboratory.

    Techniques: Staining

    A – E H&E and Nissl staining images and quantitative data of the area of ( B ) Layer V and ( C ) Layer II/III of cerebral cortex (×10 5 μm 2 ), ( D ) the neuronal density in Layer V of cerebral cortex (N cells ×10 4 /mm 3 ), and ( E ) the distribution of somatic area in Layer V of cerebral cortex (μm 2 ) of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. F – J Immunofluorescent images and quantitative data of GFAP/DAPI staining in cerebral cortex and hippocampus; the % of GFAP positive cells in ( G ) cerebral cortex and ( H ) hippocampus, and the GFAP immunointensity in ( I ) cerebral cortex and ( J ) hippocampus of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. K-N . H&E staining images and quantitative data of the thickness of (L) molecular layer and (M) granular layer of cerebellum (μm), and (N) the number of Purkinje cells in cerebellum (/mm) of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. NS not significant.

    Journal: Cell Death & Disease

    Article Title: The amino acid transporter LAT1 coordinates proper motor function at the perinatal stage

    doi: 10.1038/s41419-026-08663-8

    Figure Lengend Snippet: A – E H&E and Nissl staining images and quantitative data of the area of ( B ) Layer V and ( C ) Layer II/III of cerebral cortex (×10 5 μm 2 ), ( D ) the neuronal density in Layer V of cerebral cortex (N cells ×10 4 /mm 3 ), and ( E ) the distribution of somatic area in Layer V of cerebral cortex (μm 2 ) of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. F – J Immunofluorescent images and quantitative data of GFAP/DAPI staining in cerebral cortex and hippocampus; the % of GFAP positive cells in ( G ) cerebral cortex and ( H ) hippocampus, and the GFAP immunointensity in ( I ) cerebral cortex and ( J ) hippocampus of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. K-N . H&E staining images and quantitative data of the thickness of (L) molecular layer and (M) granular layer of cerebellum (μm), and (N) the number of Purkinje cells in cerebellum (/mm) of Slc7a5 fl/fl ( n = 3) and Syn1-Cre;Slc7a5 fl/fl mice ( n = 3) at 2 weeks of age. NS not significant.

    Article Snippet: Syn1-Cre mice (#003966) were obtained from Jackson Laboratory.

    Techniques: Staining

    A – E H&E staining images and quantitative data of the distribution of fiber area (μm 2 ) of ( B , D ) quadriceps and ( C , E ) gastrocnemius of Slc7a5 fl/fl (1 week and 2 week: n = 5, 6) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 5). F – L Immunofluorescent images of synaptophysin, neurofilament, and BTX staining and quantitative data of NMJ in EDL muscle; ( G , J ) NMJ area (μm 2 ), ( H , K ) NMJ maturity (%), and ( I , L ) NMJ innervation (denervation, partial innervation, and full innervation) (%) of Slc7a5 fl/fl (1 week and 2 week: n = 6) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 6). NS not significant. * P < 0.05, ** P < 0.01, and *** P < 0.001.

    Journal: Cell Death & Disease

    Article Title: The amino acid transporter LAT1 coordinates proper motor function at the perinatal stage

    doi: 10.1038/s41419-026-08663-8

    Figure Lengend Snippet: A – E H&E staining images and quantitative data of the distribution of fiber area (μm 2 ) of ( B , D ) quadriceps and ( C , E ) gastrocnemius of Slc7a5 fl/fl (1 week and 2 week: n = 5, 6) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 5). F – L Immunofluorescent images of synaptophysin, neurofilament, and BTX staining and quantitative data of NMJ in EDL muscle; ( G , J ) NMJ area (μm 2 ), ( H , K ) NMJ maturity (%), and ( I , L ) NMJ innervation (denervation, partial innervation, and full innervation) (%) of Slc7a5 fl/fl (1 week and 2 week: n = 6) and Syn1-Cre;Slc7a5 fl/fl mice (1 week and 2 week: n = 6). NS not significant. * P < 0.05, ** P < 0.01, and *** P < 0.001.

    Article Snippet: Syn1-Cre mice (#003966) were obtained from Jackson Laboratory.

    Techniques: Staining

    A Schematic diagram of calpeptin administration schedule followed by histological analyses in Slc7a5 fl/fl and Syn1-Cre;Slc7a5 fl/fl mice. B Kaplan–Meier survival analysis of Slc7a5 fl/fl mice and Syn1-Cre;Slc7a5 fl/fl mice treated with vehicle or calpeptin ( Slc7a5 fl/fl mice + vehicle, n = 9; Slc7a5 fl/fl mice + calpeptin, n = 7; Syn1-Cre;Slc7a5 fl/fl mice + vehicle, n = 5; Syn1-Cre;Slc7a5 fl/fl mice + calpeptin, n = 7). C – E Immunofluorescent images and quantitative data of cleaved caspase 3/ChAT/DAPI staining in lumbar spinal cord; ( D ) the number of ChAT positive cells, and ( E ) the number of cleaved caspase 3 and ChAT double positive cells of Slc7a5 fl/fl mice and Syn1-Cre;Slc7a5 fl/fl mice treated with vehicle or calpeptin ( Slc7a5 fl/fl mice + vehicle, n = 5; Slc7a5 fl/fl mice + calpeptin, n = 5; Syn1-Cre;Slc7a5 fl/fl mice + vehicle, n = 5; Syn1-Cre;Slc7a5 fl/fl mice + calpeptin, n = 5). Arrowheads indicate representative cleaved caspase 3, ChAT, and double positive cells. F – I Immunofluorescent images of synaptophysin/neurofilament/BTX staining and quantitative data of NMJ in EDL muscle; ( G ) NMJ area (μm 2 ), ( H ) NMJ maturity (%), and ( I ) NMJ innervation (%) of Slc7a5 fl/fl mice and Syn1-Cre;Slc7a5 fl/fl mice treated with vehicle or calpeptin ( Slc7a5 fl/fl mice + vehicle, n = 5; Slc7a5 fl/fl mice + calpeptin, n = 5; Syn1-Cre;Slc7a5 fl/fl mice + vehicle, n = 5; Syn1-Cre;Slc7a5 fl/fl mice + calpeptin, n = 5). * P < 0.05, ** P < 0.01, *** P < 0.001, and # P < 0.05.

    Journal: Cell Death & Disease

    Article Title: The amino acid transporter LAT1 coordinates proper motor function at the perinatal stage

    doi: 10.1038/s41419-026-08663-8

    Figure Lengend Snippet: A Schematic diagram of calpeptin administration schedule followed by histological analyses in Slc7a5 fl/fl and Syn1-Cre;Slc7a5 fl/fl mice. B Kaplan–Meier survival analysis of Slc7a5 fl/fl mice and Syn1-Cre;Slc7a5 fl/fl mice treated with vehicle or calpeptin ( Slc7a5 fl/fl mice + vehicle, n = 9; Slc7a5 fl/fl mice + calpeptin, n = 7; Syn1-Cre;Slc7a5 fl/fl mice + vehicle, n = 5; Syn1-Cre;Slc7a5 fl/fl mice + calpeptin, n = 7). C – E Immunofluorescent images and quantitative data of cleaved caspase 3/ChAT/DAPI staining in lumbar spinal cord; ( D ) the number of ChAT positive cells, and ( E ) the number of cleaved caspase 3 and ChAT double positive cells of Slc7a5 fl/fl mice and Syn1-Cre;Slc7a5 fl/fl mice treated with vehicle or calpeptin ( Slc7a5 fl/fl mice + vehicle, n = 5; Slc7a5 fl/fl mice + calpeptin, n = 5; Syn1-Cre;Slc7a5 fl/fl mice + vehicle, n = 5; Syn1-Cre;Slc7a5 fl/fl mice + calpeptin, n = 5). Arrowheads indicate representative cleaved caspase 3, ChAT, and double positive cells. F – I Immunofluorescent images of synaptophysin/neurofilament/BTX staining and quantitative data of NMJ in EDL muscle; ( G ) NMJ area (μm 2 ), ( H ) NMJ maturity (%), and ( I ) NMJ innervation (%) of Slc7a5 fl/fl mice and Syn1-Cre;Slc7a5 fl/fl mice treated with vehicle or calpeptin ( Slc7a5 fl/fl mice + vehicle, n = 5; Slc7a5 fl/fl mice + calpeptin, n = 5; Syn1-Cre;Slc7a5 fl/fl mice + vehicle, n = 5; Syn1-Cre;Slc7a5 fl/fl mice + calpeptin, n = 5). * P < 0.05, ** P < 0.01, *** P < 0.001, and # P < 0.05.

    Article Snippet: Syn1-Cre mice (#003966) were obtained from Jackson Laboratory.

    Techniques: Staining